Endocrine Abstracts

Introduction: Central obesity is the source of inflammatory factors, causing endothelial dysfunction. In central nervous system, inflammatory factors mediate neurotransmitter metabolism promoting excitotoxicity and increase oxidative stress, and a major clinical symptom is depression. Mediterranean diet (MD) resulted as a good prevention method for depression.Aim: To examine the relationship of depression with abdominal obesity and metabolic syndrome (MS...

Background: Abdominal obesity, which in fact is a metabolic syndrome (MS), is related to decreased testosterone, insulin resistance (IR), increased inflammatory factors, non-alcoholic fat liver disease (NAFLD) and risk of early atherosclerosis. Elevated inflammatory markers (CRP) may interfere with insulin signal transduction at the neuronal level inducing hypogonadotropic hypogonadism.Objective: To examine testosterone relationship with abdominal obesit...

Background and aims: The aim was to analyze insulin resistance (IR), glycoregulation disorders, lipid status, C-reactive protein (CRP), plasminogen activator inhibitor (PAI-1) and antioxidant defense in children and adolescents with pre-metabolic (Pre-MS) and metabolic (MS) syndromes.Material and methods: The study included 30 obese individuals (age 10–20 years, body mass index (BMI) or waist circumference (WC) ≥90 percentile). Three of the fo...

Background: Obesity is followed by insulin resistance (IR) and low grade inflammation. In patients with metabolic syndrome (MS) and clinicaly evident vascular complications homocystein values are higher. Hyperhomocysteinemia correlates with hyperinsulinemia and IR, resulting in oxidative stress, which causes endothelial lesions and dysfunction, promoting atherosclerosis and hypertension.Objectives: To examine homocystein levels in patients with and witho...

Aim: The aim of the study was to examine the existence of cardiovascular diseases (CVD), atherosclerotic factors and antioxidant defense in patients with central retinal artery and central retinal vein occlusions (CRAO, CRVO) and anterior ischemic optic neuropathy (AION).Materials and Methods: The study included 38 obese individuals with CRAO, CRVO and AION. Glycoregulation disorders were determined by OGTT. Lipid status was determined by spectrophotomet...

Background and Aims: Early glycoregulation disorders, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are associated with metabolic syndrome (MS). The aim of this study is: (a) to analyze parameters of insulin sensitivity, glycoregulation, lipid status, microalbuminuria (MI) and homocysteine (HCY) in patients with obesity (I), IFG (II), IGT (III) and newly diagnosed DM type 2 (IV) patients; (b) to determine the percentage of metabolic syndrome at these pati...